- PII
- 10.31857/S2686953522600751-1
- DOI
- 10.31857/S2686953522600751
- Publication type
- Status
- Published
- Authors
- Volume/ Edition
- Volume 512 / Issue number 1
- Pages
- 32-38
- Abstract
- Based on monoterpenoid (–)-isopulegol a number of new derivatives of octahydro-2H-chromene have been synthesized. The structure of the products obtained was determined by 1H and 13C NMR spectroscopy, high resolution mass spectrometry and X-ray diffraction analysis. It was shown that several synthesized compounds exhibit high analgesic activity in in vivo tests. The highest efficiency in both tests (acetic writhing and hot plate) was shown by (4S)-diastereomers of morpholinoacetamide derivatives of octahydro-2H-chromene.
- Keywords
- изопулегол реакция Принса–Риттера октагидро-2<i>Н</i>-хромен анальгетическая активность
- Date of publication
- 18.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 3
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