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RAS PresidiumДоклады Российской академии наук. Химия, науки о материалах Doklady Chemistry

  • ISSN (Print) 2686-9535
  • ISSN (Online) 3034-5111

AMINO DERIVATIVES OF ACRIDINE: SYNTHESIS, STUDY OF ANTICHOLINESTERASE AND ANTIOXIDANT ACTIVITIES

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PII
10.31857/S268695352370019X-1
DOI
10.31857/S268695352370019X
Publication type
Status
Published
Authors
A. V. Shchepochkin
  • Affiliation:
    Institute of Organic Synthesis named by I.Y. Postovsky, Ural branch of the Russian Academy of Sciences
    Ural Federal University named by the first President of Russia B.N. Yeltsin
Volume/ Edition
Volume 509 / Issue number 1
Pages
34-40
Abstract
A simple and accessible approach to the synthesis of new amine derivatives of acridine based on the direct C–H functionalization methodology was developed. The inhibitory effect of the synthesized compounds on cholinesterases and carboxylesterases, as well as their antioxidant activity, was studied. A moderate inhibition of BChE by the morpholine and pyrazole derivatives of acridine and a high anti-BChE activity of the N-methyl-piperazine one were shown.
Keywords
прямая С–Н-функционализация аминирование акридин антихолинэстеразная активность антиоксидантная активность
Date of publication
18.09.2025
Year of publication
2025
Number of purchasers
0
Views
4

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