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RAS PresidiumДоклады Российской академии наук. Химия, науки о материалах Doklady Chemistry

  • ISSN (Print) 2686-9535
  • ISSN (Online) 3034-5111

DEVELOPMENT OF APPROACHES TO THE SYNTHESIS OF ALCOXY DERIVATIVES OF PROTTREMINE ACCORDING TO POSITIONS 1 AND 9

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PII
S3034511125060043-1
DOI
10.7868/S3034511125060043
Publication type
Article
Status
Published
Authors
O.V. Ardashov
  • Occupation: PhD (chem.), senior researcher
  • Affiliation: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
K.P. Volcho
  • Occupation: Dr. of Science, chief researcher
  • Affiliation: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
N.F. Salakhutdinov
  • Occupation: Corresponding Member of the RAS, Dr. of Sciences, Head of the Department of Medicinal Chemistry
  • Affiliation: N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
Volume/ Edition
Volume 525 / Issue number 1
Pages
44-54
Abstract
The paper presents approaches to the synthesis of ether derivatives of the antiparkinsonian agent Prottremine ((1,2,6)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol) at positions 1 and 9. The synthesis of the 1-methoxy derivative was carried out by isomerization of verbenol epoxide methyl ether on K10 montmorillonite clay with a yield of 31%. The synthesis of 9-MeO-, 9--PrO- and 9--BuO-derivatives was developed on the basis of the 9-Br-derivative by sequential introduction of methoxymethyl protection, interaction with the corresponding alcoholates and removal of the protecting groups. The yield of the target compounds in three steps was 40–59%.
Keywords
Проттремин терпен простые эфиры метоксиметильная защита изомеризация болезнь Паркинсона
Date of publication
01.01.2026
Year of publication
2026
Number of purchasers
0
Views
54

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