- PII
- 10.31857/S2686953524050035-1
- DOI
- 10.31857/S2686953524050035
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 518 / Issue number 1
- Pages
- 32-40
- Abstract
- A method for synthesis of two new types of polysiloxane-based films is proposed: with introduced chitosan and with introduced sodium bicarbonate with its subsequent removal. It was found that the obtained films have a branched internal structure of channels suitable for further filling with biologically active substances. The study of the hydrophobicity of the obtained films, in comparison with pure polysiloxane films, showed an insignificant (no more than 6%) decrease in the equilibrium wetting edge angle, as well as equalization of its values from the outer and inner sides, compared with films without modification. A comprehensive in vitro study demonstrated the promising use of polysiloxane films with introduced chitosan, since they do not have a reliable toxic effect on the studied cells. Films of pure polysiloxane and polysiloxane with the use of sodium hydrogen carbonate had a toxic effect on the investigated cells and acidified the medium. All samples were found to be non-adhesive to cells.
- Keywords
- силоксан хитозан гидрокарбонат натрия цитотоксичность смачиваемость полимерные пленки
- Date of publication
- 18.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 4
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